Towards an alternative to Gillespie's Algorithm for simulating biochemical reactions

Day - Time: 15 March 2011, h.11:00
Place: Area della Ricerca CNR di Pisa - Room: C-29
  • Davide Chiarugi (Dipartimento di Scienze Matematiche e Informatiche, Università di Siena)

Ercan Engin Kuruoglu


Gillespie's Stochastic Simulation Algorithm (SSA) is probably the most used method for the stochastic simulation of biochemical reactions. The results of some recent wet-lab experiments on single enzyme molecules suggest that the theoretical framework on which the SSA grounds could not be adequate in the case of anzymatically catalysed reactions. Some proposals aiming at finding new methods for the stochastic simulation of biochemical reactions will be presented.